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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۱۰، شماره ۴، صفحات ۲۲۶-۲۳۳
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عنوان انگلیسی Efficacy of Hypozalix spray and Propolis mouthwash for prevention of chemotherapy-induced oral mucositis in leukemic patients: A double blind randomized clinical trial
چکیده انگلیسی مقاله Background: Oral mucositis is the chief complication of head and neck chemotherapy. The current study was conducted to evaluate Hypozalix artificial saliva and propolis mouthwash efficacy for the prevention of chemotherapy-induced oral mucositis in leukemic patients. Materials and Methods: The present double-blind clinical trial was carried out on 72 patients, undergoing chemotherapy. The patients were assigned to 3 groups. In the control group, CHX mouthwash and fluconazole were used by the subjects. In groups 1 and 2, Hypozalix and propolis mouthwashes were added to the combination therapy used in the control group. The results were compared between the three groups after 14 days. Results: Based on the results, 50% of the patients in the control group, 50% in group 1 and 95.8% in group 2 reported recovery from xerostomia. 29.17% of the patients in the control group, 87.5% in group 1 and 70.83% in group 2 exhibited easy mastication. 87.5%, 62.5% and 91.67% of the patients in group 2 exhibited easy swallowing, less waking up and a decrease in burning sensation, respectively(P< 0.05). Propolis resulted in a significantly greater decrease in the severity of mucositis compared to Hypozalix and control group (P< 0.05). Conclusion: use of Hypozalix spray or propolis mouthwash in association with CHX mouthwash and fluconazole simultaneously at start of chemotherapy, resulted in a decrease in chemotherapy complications after 14 days. in many cases use of propolis mouthwash yielded better results and the patients exhibited a greater tendency to continue to use it.
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نویسندگان مقاله حسین اسلامی | hosein eslami
department of oral medicine, faculty dentistry, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

فیروز پورعلی بابا | firouz pouralibaba
department of oral medicine, faculty dentistry, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

پریسا فلسفی | parisa falsafi
department of oral medicine, faculty dentistry, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

سپیده بهلولی | sepideh bohluli
department of oral medicine, faculty dentistry, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

بابک نجاتی | babak najati
oncology research center, ghazi hospital, tabriz medical university, tabriz –iran


رامین نگهداری | ramin negahdari
department of prosthodontics, faculty dentistry, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

میلاد غنی زاده | milad ghanizadeh
post-graduated student of oral and maxillofacial surgery,dental faculty, tabriz university of medical sciences,tabriz,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/3067
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319611.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Basic Research
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