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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۱۰، شماره ۱، صفحات ۳۷-۴۲
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عنوان انگلیسی Immunohistochemical evaluation of myofibroblast density in odontogenic cysts and tumors
چکیده انگلیسی مقاله Background. The aim of this study was to investigate myofibroblast (MF) density in a broad spectrum of odontogenic cysts and tumors and the relation between the density of MFs and the clinical behavior of these lesions. Methods. A total of 105 cases of odontogenic lesions, including unicystic ameloblastoma (UAM), solid ameloblastoma (SA), odontogenic keratocyst (OKC), dentigerous cyst (DC), radicular cyst (RC) (15 for each category), and odontogenic myxoma (OM), adenomatoid odontogenic tumor (AOT), calcifying odontogenic cyst (COC) (10 for each category), were immunohistochemically stained with anti-α-smooth muscle actin antibody. The mean percentage of positive cells in 10 high-power fields was considered as MF density for each case. Results. A statistically significant difference was observed in the mean scores between the study groups (P 0.05). The number of MFs was significantly higher in OKC and lower in COC compared to other odontogenic cysts (P = 0.007 and P = 0.045, respectively). Conclusion. The results of the present study suggest a role for MFs in the aggressive behavior of odontogenic lesions. MFs may represent an important target of therapy, especially for aggressive odontogenic lesions. Our findings support the classification of OKC in the category of odontogenic tumors.
کلیدواژه‌های انگلیسی مقاله myofibroblasts,odontogenic cysts,odontogenic tumors
نویسندگان مقاله مریم کوه سلطانی | maryam kouhsoltani
assistant professor, department of oral and maxillofacial pathology, faculty of dentistry, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

منیره حلیمی | monireh halimi
associate professor, department of pathology, faculty of medicine, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

گلچین جباری | golchin jabbari
post-graduate student, department of endodontics, faculty of dentistry, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/2081
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319646.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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