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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۹، شماره ۳، صفحات ۱۶۶-۱۷۴
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عنوان انگلیسی Quantitative immunoexpression of EGFR in oral potentially malignant disorders: oral leukoplakia and oral submucous fibrosis
چکیده انگلیسی مقاله Background and aims. Many oral squamous cell carcinomas develop from potentially malignant disorders (PMDs) which include a variety of lesions and conditions characterized by an increased risk for malignant transformation. This study evaluated the quantitative expression of EGFR in normal oral mucosa, oral leukoplakia and oral submucous fibrosis to predict the malignant risk in compliance with the intensity of staining with EGFR. Materials and methods. Thirty subjects were included in the study, consisting of 10 oral leukoplakia (OL), 10 oral submucous fibrosis (OSMF) and 10 normal oral mucosa (NOM) as the control group. Owing to the histopathological confirmation of precancerous state of tissue, 4-µm-thick sections of tissue were taken from paraffin-embedded wax blocks for immunohistochemical staining for EGFR. Results. All the control cases showed positive expression for EGFR, while 20% of oral leukoplakia and 40% of OSMF cases showed strong expression (3+), 40% of OL and 30% of OSMF cases showed weak expression (2+), and 40% of OL and 30% of OSMF cases showed poor expression (1+) compared to controls (P=0.012). Conclusion. EGFR expression levels in the premalignant lesion appear to be a sensitive factor in predicting the neoplastic potential. This suggests that EGFR may serve as a biological marker to identify high-risk subgroups and guide prophylactic therapy with chemopreventive drugs or surgical intervention to prevent progression to carcinoma. Hence, further investigations in the direction of chemopreventive trials with a larger sample size are suggested to determine its role in the head and neck tumorigenesis.
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نویسندگان مقاله naga jyothi meka | naga jyothi meka
sri sai college of dental surgery


sridevi ugrappa | sridevi ugrappa
lecturer, faculty of dentistry,aimst dental institute, aimst university, semeling, 08100, bedong, malaysia


nagalaxmi velpula | nagalaxmi velpula
sri sai college of dental surgery


sravan کومار | sravan kumar
sri sai college of dental surgery


kotyanaik maloth | kotyanaik maloth
mamata dental college


srikanth kodangal | srikanth kodangal
sri sai college of dental surgery


lalitha ch | lalitha ch
sri sai college of dental surgery


stuti goyal | stuti goyal
sri sai college of dental surgery
نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/1863
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319668.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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