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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۹، شماره ۱، صفحات ۲۳-۲۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus
چکیده انگلیسی مقاله Background and aims. Standard treatment of oral lichen planus (OLP) includes topical or systemic corticosteroids that have many adverse effects. A trend toward alternative natural or herbal drugs has attended recently. This study was conducted to evaluate the effect of quercetin in treatment of erosive-atrophic OLP. Materials and methods. Thirty patients participated in this randomized clinical trial from April 2010 to June 2010 (Trial Registration Number: NCT01375101). Patients were randomly allocated in two groups. Both groups received the standard treatment (dexamethasone mouthwash and nystatin suspension). Experimental group received oral 250 mg quercetin hydrate capsules (bid) and the control group received placebo capsules. The pain and severity of the lesions were recorded at the initial visit and the follow-ups. All recorded data were analyzed with chi-square, Mann-Whitney, t-test, Wilcoxon and Friedman tests using SPSS 11.5. Results. There were no significant differences between the two groups in severity of the lesions and pain in the follow-ups. According to the Friedman test, there was a significant reduction in pain (P = 0.01) and severity indices (P = 0.00) in the case group. These differences were not observed in the control group (P = 0.26, SI; and P = 0.86, PI). No adverse effect of quercetin was reported. Conclusion. According to the results, no significant therapeutic effect can be considered for quercetin in treatment of OLP.
کلیدواژه‌های انگلیسی مقاله Clinical trial,lichen planus,quercetin,oral
نویسندگان مقاله مریم امیرچقماقی | maryam amirchaghmaghi
associate professor of oral medicine


زهرا دلاوریان | zahra delavarian
associate professor of oral medicine


مهرداد ایرانشاهی | mehrdad iranshahi
associate professor of pharmacognosy


محمد تقی شاکری | mohammad taghi shakeri
associate professor of biostatics


پگاه مسنن مظفری | pegah mosannen mozafari
assistant professor


امیر هوشنگ محمدپور | amir hushang mohammadpour
assistant professor of pharmacodinamy


فاطمه فرازی | fatemeh farazi
assistant professor of oral medicine


میلاد iranshahy | milad iranshahy
phd student of pharmacognosy
نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/1480
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319692.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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