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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۸، شماره ۴، صفحات ۲۳۵-۲۳۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of iranian propolis on salivary total antioxidant capacity in gamma-irradiated rats
چکیده انگلیسی مقاله Background and aims. The antioxidant and anti-inflammatory properties of propolis were studied. Since saliva contains antioxidants and radiotherapy of the head and neck mainly affects the saliva, salivary antioxidant defensive mechanism is compromised with oxidative stress produced by radiation therapy. Therefore, the aim of the present study was to investigate the effect of propolis on salivary total antioxidant capacity in irradiated rats. Materials and methods. The study was conducted on 28 rats, 7‒11 weeks of age (160±20 g), divided into four groups: saline with no radiation (S), saline and radiation (SR), propolis with no radiation (P) [400 mg/kg IP], propolis and radiation (PR) [400 mg/kg IP]. SP and PR were exposed to 15 Gy of gamma irradiation for 7 minutes and 39 seconds. The rats received intraperitoneal injections each day for 10 days, and their tongues and lips were daily examined for mucositis; saliva sample were also taken three times on days 0, 6, and 10. Results. Mucositis incidence appeared to be delayed in the PR compared to the SR, and the severity was significantly higher in the SR compared to the PR. No significant alterations were observed in salivary antioxidant levels during the experiment, except the SR group in which a significant reduction was found. Conclusion. Propolis might reduce and delay radiation-induced mucositis in animal models; it might be able to prevent the reduction in salivary antioxidant levels in irradiated rats as well.
کلیدواژه‌های انگلیسی مقاله Antioxidant activity,propolis,saliva,radiation therapy
نویسندگان مقاله سارا عاقل | sara aghel
assistant professor of oral medicine department


مهدی پورامیر | mahdi pouramir
professor of biochemistry,


علی اکبر مقدم نیا | ali akbar moghadamnia
professor of pharmacology


داریوش مسلمی | dariush moslemi
assistnat professor of radiation oncology


طاهره ملانیا | tahere molania
assistant professor


لیلا قاسمی | leila ghassemi
general dentist


مینا مطلب نژاد | mina motallebnejad
associate professor, cellular amp;amp; molecular biology research center, department of oral medicine, babol university of medical sciences, babol

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/659
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319707.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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