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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۸، شماره ۱، صفحات ۳۵-۳۹
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عنوان انگلیسی Salivary total antioxidant capacity and lipid peroxidation in patients with erosive oral lichen planus
چکیده انگلیسی مقاله Background and aims. Oral lichen planus is a common chronic inflammatory disease of the oral mucosa with malignant potential, pathogenesis of which is not still well known. Free radicals and reactive oxygen species can play an important role in the pathogenesis of oral lichen planus. The aim of this study was to investigate salivary oxidative stress and antioxidant systems in patients with oral lichen planus. Materials and methods. In this case-control study, 30 patients with oral lichen planus (case group) and 30 age- and gender-matched healthy subjects (control group), referring to Dental School of Babol University of Medical Sciences, were selected using simple sampling method. Unstimulated saliva of the two groups was collected. Salivary total antioxidant capacity (TAC) and lipid peroxidation products were investigated and compared, using ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substance (TBARS) methods, respectively. Data were analyzed using Student’s t-test. Results. The mean and standard deviation of salivary TAC in patients with oral lichen planus (297.23 ± 149.72 μM) was significantly lower than that in the controls (791.43±183.95 μM; P < 0.0001), and mean and standard deviation of salivary malondialdehyde (MDA) (0.49 ± 0.30 μM) was remarkably higher in oral lichen planus patients compared to the control group (0.15 ± 0.11 μM) (P < 0.0001). TAC was also reduced in both groups in line with an increase in the level of MDA (P < 0.0001, r = −0.48). Conclusion. The results of this study suggested that an increase in oxidative stress and an imbalance in antioxidant defense system in the saliva of oral lichen planus patients may be involved in the pathogenesis of oral lichen planus.
کلیدواژه‌های انگلیسی مقاله antioxidant,lichen planus, lipid peroxidation, saliva
نویسندگان مقاله آتنا شیرزاد | atena shirzad
assistant of oral medicine


مهدی پورامیر | mahdi pouramir
professor of biochemistry, babaol university of medical sciences


مریم سیدمجیدی | maryam seyedmajidi
assistant professor of oral pathology, dental material research center, dnetal school, babol university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

نیلوفر جنابیان | niloofar jenabian
assistant professor of periodontology, dental school, babol university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

علی بیژنی | ali bijani
medical doctor, babol univeristy of medical sicneces


مینا مطلب نژاد | mina motallebnejad


نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/627
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319741.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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