این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۷، شماره ۴، صفحات ۲۱۸-۲۲۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of the effect of two systemic doses of HESA-A on prevention of induced tongue neoplasm in rats
چکیده انگلیسی مقاله Background and aims. The aim of the present study was to compare the inhibitory effects of two systemic doses of HESA-A on prevention of 4-NQO-induced tongue neoplasms in rats. This study evaluated weight and histopathological changes. Materials and methods. Forty-eight male Sprague Dawley rats were divided into four groups of A, B, C and D of each 12 rats. The rats in groups B to D received 30 ppm of 4-Nitroquinoline-1-oxide (4-NQO) in drinking water for 12 weeks. When feeding with 4-NQO was initiated, the rats in groups B and C received HESA-A at doses of 250 and 500 mg/kg, respectively, 3 times a week. Body weights were measured three times a week. At the end, the rats were euthanized and the tongue was removed. Histological evaluations for carcinogenesis were carried out under a light microscope. Results. The mean body weights of rats in groups B, C and D were significantly lower than that in group A (P < 0.05). There were no significant differences in weight changes between groups B, C and D. In the present study, after 12 weeks of treatment, Tongue specimens in groups B and C did not exhibit severe dysplastic changes; however, concurrent hyperplasia, without atypia and mild-to-moderate dysplastic changes were detected. These changes were significantly less than those in group D, with significant differences between group D and groups A, B and C (P< 0.001, P< 0.01 and P< 0.05, respectively). Conclusion. HESA-A has dose-dependent inhibitory effects on the development of neoplasms of the tongue.
کلیدواژه‌های انگلیسی مقاله 4-nitroquinoline-1-oxide,HESA-A,rat,tongue neoplasm
نویسندگان مقاله معصومه مهدی پور | masoumeh mehdipour
associate professor of oral medicine ,shahid beheshti dental school,


علی تقوی زنوز | ali taghavi zenouz
associate professor of oral medicine ,tabriz dental school, tabriz university

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

مهران مسگری عباسی | mehran mesgari abbasi
dvm doctor of veterinary medicine , drug applied research center of tabriz university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

داریوش مهاجری | daryoush mohajeri
associate professor of veterinary medicine, department of pathobiology, faculty of veterinary medicine, tabriz branch, islamic azad university, tabriz, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

حسین دامغانی | hossein damghani
post-graduate student, department of oral pathology, faculty of dentistry, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

ساناز حلی | sanaz helli
post-graduate student, department of oral medicine, faculty of dentistry, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

بیتا عبداللهی | bita abdollahi


نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/920
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319751.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات