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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۷، شماره ۴، صفحات ۲۳۰-۲۳۷
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عنوان انگلیسی Detection of Helicobacter pylori in oral lesions
چکیده انگلیسی مقاله Background and aims. Helicobacter pylori is a microaerophilic gram-negative spiral organism. It is recognized as the etiologic factor for peptic ulcers, gastric adenocarcinoma and gastric lymphoma. Recently, it has been isolated from dental plaque and the dorsum of the tongue. This study was designed to assess the association between H. pylori and oral lesions such as ulcerative/inflammatory lesions, squamous cell carcinoma (SCC) and primary lymphoma. Materials and methods. A total of 228 biopsies diagnosed as oral ulcerative/inflammatory lesions, oral squamous cell carcinoma (OSCC) and oral primary lymphoma were selected from the archives of the Pathology Department. Thirty-two samples that were diagnosed as being without any pathological changes were selected as the control group. All the paraffin blocks were cut for hematoxylin and eosin staining to confirm the diagnoses and then the samples were prepared for immunohistochemistry staining. Data were collected and analyzed. Results. Chi-squared test showed significant differences between the frequency of H. pylori positivity in normal tissue and the lesions were examined (P=0.000). In addition, there was a statistically significant difference between the lesions examined (P=0.042). Chi-squared test showed significant differences between H. pylori positivity and different tissue types except inside the muscle layer as follows: in epithelium and in lamina propria (P=0.000), inside the blood vessels (P=0.003), inside the salivary gland duct (P=0.036), and muscle layer (P=0.122). Conclusion. There might be a relation between the presence of H. pylori and oral lesions. Therefore, early detection and eradication of H. pylori in high-risk patients are suggested.
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نویسندگان مقاله سوسن ایرانی | soussan irani
hamadan university


علیرضا منصف اصفهانی | alireza monsef esfahani


فرحناز بیداری زره پوش | farahnaz bidari zerehpoush


نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/785
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319753.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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