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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۷، شماره ۲، صفحات ۸۶-۹۰
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عنوان انگلیسی Efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia
چکیده انگلیسی مقاله Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a one-week washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P< 0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region.
کلیدواژه‌های انگلیسی مقاله Bromhexine,pilocarpine,radiotherapy,xerostomia
نویسندگان مقاله فرید عباسی | farid abbasi
associated professor,dental faculty, shahed university

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

ساره فرهادی | sareh farhadi
assisstant professor,dental faculty, shahed university

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

مصطفی اسماعیلی | mostafa esmaili
assistant professor,dental faculty, shahed university

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/379
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319771.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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