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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۷، شماره ۱، صفحات ۱۵-۲۱
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عنوان انگلیسی Subcutaneous connective tissue reactions to various endodontic biomaterials: an animal study
چکیده انگلیسی مقاله Background and aims. Biocompatibility of root-end filling materials is a matter of debate. The aim of this study was to compare the biocompatibility of a variety of commercial ProRoot WMTA cements and a resin-based cement (Geristore®) with different pH values of setting reaction and different aluminum contents, implanted into the subcutaneous connective tissue of rats at various time intervals. Materials and methods. Fifty Sprague-Dawley rats were used in this study. Polyethylene tubes were filled with Angelus WMTA, ProRoot WMTA, Bioaggregate, and Geristore. Empty control tubes were implanted into subcutaneous tissues and harvested at 7-, 14-, 28- and 60-day intervals. Tissue sections of 5 μm were stained with hematoxylin and eosin and observed under a light microscope. Inflammatory reactions were categorized as 0, none (without inflammatory cells); 1, mild (inflammatory cells ≤25); 2, moderate (25–125 inflammatory cells); and 3, severe (>125 inflammatory cells). Statistical analysis was performed with Kruskal-Wallis and Mann Whitney U tests. Results. ProRoot WMTA and Angelus elicited significantly less inflammation than other materials (P< 0.05). After 7 days, however, all the materials induced significantly more inflammation than the controls (P< 0.05). Angelus-MTA group exhibited no significant differences from the Bioaggregate group (P=0.15); however, ProRoot WMTA elicited significantly less inflammation than Bioaggregate (P=0.02). Geristore induced significantly more inflammation than other groups (P< 0.05). Conclusion. Geristore induced an inflammatory response higher than ProRoot WMTA; therefore, it is not recommended for clinical use.
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نویسندگان مقاله محمد علی صغیری | mohammad ali saghiri


نادر تنیده | nader tanideh


franklin گارسیا godoy | franklin garcia godoy


مهرداد لطفی | mehrdad lotfi


کسری کرمی فر | kasra karamifar


داریوش امانت | dariush amanat


نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/480
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319779.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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