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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۶، شماره ۴، صفحات ۱۴۳-۱۴۷
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عنوان انگلیسی Evaluation of serum TNF-α and TGF-β in patients with oral lichen planus
چکیده انگلیسی مقاله Background and aims. The role of cytokines in the immunopathogenesis of oral lichen planus (OLP) has received much attention. The aim of this study was to evaluate the serum levels of TNF-α and TGF-β in patients with OLP in an Iranian population. Materials and methods. Thirty-two patients with OLP and 32 age-matched healthy volunteers as a control group were included in this study. Serum tests including TNF-α and TGF-β was performed in both groups. Data analysis was performed using descriptive statistics and Mann–Whitney U test using SPSS software version 16.0. Results. The mean of TNF-α in study and control groups were 157 ± 115 pg/ml and 14 ± 10 pg/ml, respectively. The difference between the two means was statistically significant (P < 0.001). Moreover, the mean of TGF-β in study and control groups were 155 ± 26 pg/ml and 175 ± 57 pg/ml, respectively. The difference between the two means was statistically significant (P = 0.03). Conclusion. According to the results of the present study, there was a significant decrease in the serum levels of TGF-β and a significant increase in the serum levels of TNF-α in patients with oral lichen planus. The increase in TNF-α serum levels in patients with OLP explains the inflammatory process in the course of the disease.
کلیدواژه‌های انگلیسی مقاله Oral lichen planus,TNF-α, TGF-β.
نویسندگان مقاله علی تقوی زنوز | ali taghavi zenouz
faculty of dentistry, tabriz university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

فیروز پورعلی بابا | firoz pouralibaba


زهره بابالو | zohreh babaloo


معصومه مهدی پور | masoumeh mehdipour


زهرا جمالی | zahra jamali


نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/266
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319790.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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