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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۶، شماره ۳، صفحات ۱۰۳-۱۰۷
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عنوان انگلیسی Vascular endothelial growth factor and Ki-67 antigen expression in relation to age and gender in oral squamous cell carcinoma
چکیده انگلیسی مقاله Background and aims. Vascular endothelial growth factor (VEGF) and Ki-67 antigen are contributing factors in this process cell proliferation and new blood vessels formation in tumor progression. This study was conducted to examine the relationship between the expression of VEGF and Ki-67 and gender and age of patients with oral squamous cell carcinoma (OSCC). Materials and methods. Twenty-three archival samples of well-differentiated OSCC were examined immunohistochemically and assessed by obtaining Total Score (TS = proportion score × staining index). For statistical analysis, t-test and Pearson’s correlation were employed. P≤0.05 was considered statistically significant. Results. The differences in VEGF expression between males and females (P = 0.43) and different ages (P = 0.88) were not significant. The differences in Ki-67 expression was between males and females (P = 0.67) and different ages (P = 0.88) were also not significant. A positive correlation of VEGF and Ki-67 expression was observed in males and females in addition to ≤ 60 years age group (r = 0.22, r = 0.008, and r = 0.58, respectively; P 60 years group (r = −0.48, P < 0.05). Conclusion. The expression of VEGF and Ki-67 between males and females and different ages were not significant among oral squamous cell carcinoma cases evaluated.
کلیدواژه‌های انگلیسی مقاله Carcinoma,immunohistochemistry,Ki-67 antigen,VEGF
نویسندگان مقاله نوشین جلایر نادری | noushin jalayer naderi
oral and maxillofacial pathology dept. , faculty of dentistry , shahed university

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

فرخ تیرگری | farrokh tirgari
cancer institute , tehran university of medical sciences. tehran. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فرزین اسماعیلی | farzin esmaili


فرانک پاک طینت | faranak paktinat
dentist


زهرا کشاورز | zahra keshavarz


نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/313
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319800.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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