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Journal of Dental Research, Dental Clinics, Dental prospects، جلد ۶، شماره ۱، صفحات ۱۷-۲۰
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عنوان انگلیسی Nucleolar organizer regions in oral squamous cell carcinoma
چکیده انگلیسی مقاله Background and aims. Several diagnostic methods are being employed to detect benign and malignant lesions, one of which is silver nitrate staining for organizer regions. The number of nucleolar organizing regions (NORs) can be used to show the degree of cell activity or metabolism in pathologic lesions. This study was designed to evaluate NORs as determinants of precancerous and squamous cell carcinoma. Materials and methods. A silver colloid technique was applied on paraffin sections of 40 cases of oral squamous cell carcinoma and 25 cases of precancerous lesions; 15 specimens of normal epithelium were selected for the control group. After staining with silver nitrate, argyrophilic nucleolar organizer regions (AgNORs) were counted in 100 epithelial cells in three groups with the use of an oil immersion and ×1000 objective lens. One-way ANOVA and a post hoc Tukey test were used for statistical analysis. Results. The mean numbers and standard deviations of AgNORs were 1.58 ± 0.76 in normal epithelium, 2.1 ± 1.05 in precancerous lesions and 2.43 ±1.33 in squamous cell carcinoma (SCC). There were statistically significant differences in AgNORs numbers between the groups (P< 0.001) and significant differences in precancerous lesions between dysplastic and non-dysplastic epithelia (P< 0.001). The mean AgNORs count per nucleus increased from healthy epithelium to precancerous lesion to SCC. Conclusion. This study suggests that the silver staining technique for the detection of NORs (AgNOR) can be used to distinguish precancerous lesions and benign and malignant lesions.
کلیدواژه‌های انگلیسی مقاله AgNORs,epithelium,squamous cell carcinoma
نویسندگان مقاله منیر مرادزاده خیاوی | monir moradzadeh khiavi


سپیده وثوق حسینی | sepideh vosoughhosseini


منیره حلیمی | monire halimi


سید مصطفی محمودی | seyyed mostafa mahmoudi


اصغر یاراحمدی | asghar yarahmadi


نشانی اینترنتی http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/318
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/183/article-183-319814.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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